Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPeta (IC50=36 pM) and HPTPgamma (100 pM)[1].
Molecular Weight:
586.70
Purity:
99.18
CAS Number:
[1008510-37-9]
Formula:
C26H26N4O6S3
Target:
Phosphatase,Tie
Application Notes:
MCE Product type: Reference compound
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