Elsulfavirine (sodium), CAS [[867365-40-0]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-109056A
Supplier Catalog Number:
HY-109056A
Alternative Catalog Number:
MCE-HY-109056A-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
R-1206 (sodium)
Elsulfavirine sodium (R-1206 sodium) is an orally active human carbonic anhydrase (carbonic anhydrase, CA) inhibitor and an allosteric inhibitor of HIV-1 non-nucleoside reverse transcriptase (NNRT). Elsulfavirine sodium also targets and blocks the interaction between adenylosuccinate lyase (ADSL) and insulin-induced gene proteins INSIG1/2, blocks SREBP-1-mediated de novo lipid synthesis, and inhibits the proliferation of liver cancer cells. The combination of Elsulfavirine sodium and Lenvatinib (HY-10981) produces a synergistic anti-tumor effect. Elsulfavirine sodium is converted into the active metabolite VM1500A in vivo, blocks the DNA polymerase activity of reverse transcriptase, and inhibits HIV-1 replication. Elsulfavirine sodium exhibits a Ki of 1960 nM-52400 nM against human carbonic anhydrase isoforms including I, VII, VI, VA, VB, IX, XIII, XIV. Elsulfavirine sodium is used in studies related to HIV-1 infection and liver cancer[1][2][3][4].
