Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively[1]. Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib has the potential for Alzheimers disease and rheumatoid arthritis research[1][2].
Molecular Weight:
461.60
Purity:
99.68
CAS Number:
[1142363-52-7]
Formula:
C27H35N5O2
Target:
c-Fms
Application Notes:
MCE Product type: Reference compound
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