Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity[1][2][3].
Molecular Weight:
518.92
Purity:
99.84
CAS Number:
[1028486-01-2]
Formula:
C27H20ClFN4O4
Target:
Apoptosis,Aurora Kinase,Autophagy
Application Notes:
MCE Product type: Reference compound
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