MK-0752 is a potent, orally active and specific gamma-secretase inhibitor, showing dose-dependent reduction of Abeta40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Abeta in vivo[1][2].
Molecular Weight:
442.90
Purity:
99.35
CAS Number:
[471905-41-6]
Formula:
C21H21ClF2O4S
Target:
gamma-secretase
Application Notes:
MCE Product type: Reference compound
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