FTI-277 (TFA), CAS [[1217447-06-7]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-110038
Supplier Catalog Number:
HY-110038
Alternative Catalog Number:
MCE-HY-110038-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
FTI-277 TFA is a farnesyltransferase (FTase) inhibitor. FTI-277 TFA inhibits Ras farnesylation, blocks the phosphorylation of downstream ERK1/2 and mTOR, and reduces membrane-bound active N-ras protein. FTI-277 TFA activates caspase 3, upregulates Bim expression, induces cell apoptosis, suppresses regulatory T cell expansion, enhances macrophage phagocytosis, and improves bacterial clearance. FTI-277 TFA activates the PI3K/Akt signaling pathway, inhibits osteoblast differentiation, and reduces the proliferation ability of neuroblastoma cells. FTI-277 TFA can be used in research related to head and neck squamous cell carcinoma, neuroblastoma, sepsis, and vascular calcification[1][2][3][4].
