CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC50s of 3.2 and 6.6 µM for human Hsp90beta and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits key endothelial and tumor cell functions implicated in invasion and angiogenesis[1].
Molecular Weight:
352.38
Purity:
99.19
CAS Number:
[171009-07-7]
Formula:
C20H20N2O4
Target:
Apoptosis,HSP
Application Notes:
MCE Product type: Reference compound
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