VO-OHPic is a reversible, noncompetitive PTEN inhibitor with an human IC50 value of 46 nM. VO-OHPic inhibits PTEN signaling, activates Akt-GSK3beta and Nrf-2/HO-1 pathways, induces apoptosis resistance and elevates IL-10 levels. VO-OHPic inhibits autophagy, ferroptosis and oxidative stress. VO-OHPic can be used for the research of acute myocardial infarction, intervertebral disc degeneration, cardiomyopathy and cancer[1][2][3][4][5][6].
Molecular Weight:
361.16
CAS Number:
[675848-25-6]
Formula:
C12H10N2O8V
Target:
Akt,Apoptosis,Autophagy,Ferroptosis,Interleukin Related,Keap1-Nrf2,PTEN,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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