Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects[1][2][3][4][5].
Molecular Weight:
630.44
Purity:
99.56
CAS Number:
[412960-54-4]
Formula:
C27H25Cl2N7O7
Target:
Apoptosis,p97
Application Notes:
MCE Product type: Reference compound
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