NS8593 hydrochloride is a potent and selective small conductance Ca2+-activated K+ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3-mediated currents with a Kd value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca2+-dependently (Kds of 0.42, 0.60, and 0.73 µM, respectively, at 0.5 µM Ca2+), and does not affect the Ca2+-activated K+ channels of intermediate and large conductance (hIK and hBK channels, respectively)[1][2].
Molecular Weight:
299.80
Purity:
99.86
CAS Number:
[875755-24-1]
Formula:
C17H18ClN3
Target:
Potassium Channel
Application Notes:
MCE Product type: Reference compound
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