JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-alpha, IL-1beta, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively[1]. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607[2].
Molecular Weight:
597.36
Purity:
99.27
CAS Number:
[188791-09-5]
Formula:
C25H33Cl4N3O5
Target:
Interleukin Related
Application Notes:
MCE Product type: Reference compound1
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