VU0422288 (ML396) is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice[1][2].
Molecular Weight:
360.19
Purity:
99.94
CAS Number:
[1630936-95-6]
Formula:
C17H11Cl2N3O2
Target:
mGluR
Application Notes:
MCE Product type: Reference compound
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