BRD9876 is the rigor inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the alpha4-alpha6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research[1][2][3][4].
Molecular Weight:
234.30
Purity:
99.37
CAS Number:
[32703-82-5]
Formula:
C16H14N2
Target:
Kinesin,Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound
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