ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 µM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2].
Molecular Weight:
446.50
Purity:
99.76
CAS Number:
[1432500-66-7]
Formula:
C26H26N2O5
Target:
Keap1-Nrf2,Quinone Reductase
Application Notes:
MCE Product type: Reference compound
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