(R,S,R)-ML334 is the isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 µM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2].
Molecular Weight:
446.50
Purity:
98.57
CAS Number:
[1432065-33-2]
Formula:
C26H26N2O5
Target:
Drug Isomer
Application Notes:
MCE Product type: Reference compound
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