Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis[1][2][3].
Molecular Weight:
438.65
Purity:
99.62
CAS Number:
[300815-04-7]
Formula:
C13H14Cl3N7O4
Target:
APC,Mitosis
Application Notes:
MCE Product type: Reference compound1
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