Ischemin sodium is a CBP bromodomain inhibitor that inhibits p53 interaction with CBP and transcriptional activity in cells. Ischemin sodium salt inhibits p53-induced p21 activation with an IC50 value of 5 µM. Ischemin sodium salt also prevents apoptosis in ischemic cardiomyocytes. Ischemin sodium salt can be used in the study of cardiovascular diseases (such as myocardial ischemia)[1].
Molecular Weight:
357.36
Purity:
99.32
Formula:
C15H16N3NaO4S
Target:
Apoptosis,Epigenetic Reader Domain,MDM-2/p53
Application Notes:
MCE Product type: Reference compound1
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