KRP-109 is a neutrophil elastase (NE) inhibitor with activity in reducing lung inflammation. KRP-109 improves survival in mouse models and reduces the number of neutrophils and inflammation in the alveolar walls. KRP-109 significantly reduced cell and neutrophil counts in bronchoalveolar lavage fluid, as well as cytokine levels such as interleukin 1beta and macrophage inflammatory protein 2. KRP-109 can be used in the research of severe pneumonia[1].
Molecular Weight:
394.47
CAS Number:
[1015439-77-6]
Formula:
C22H26N4O3
Target:
Elastase
Application Notes:
MCE Product type: Reference compound
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