Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 µM). Icilin is a super-cooling agent [1][2]. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response[3].
Molecular Weight:
311.29
Purity:
99.26
CAS Number:
[36945-98-9]
Formula:
C16H13N3O4
Target:
TRP Channel
Application Notes:
Reference compound
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