Butyrolactone I is an orally active and ATP-competitive inhibitor of CDK1. Butyrolactone I inhibits NF-kappaB, cdc2 kinase, Bax, ROS production, modulates the PERK/CHOP. Butyrolactone I mitigates heat-stress-induced Apoptosis. Butyrolactone I shows anti-inflammatory and intestinal protective activity. Butyrolactone I has antitumor effects against non-small cell lung, small cell lung, prostate cancer and leukemia. Butyrolactone I can be used in NASH research[1][2][3][4][5][6][7].
Molecular Weight:
424.44
Purity:
99.80
CAS Number:
[87414-49-1]
Formula:
C24H24O7
Target:
Apoptosis,Bcl-2 Family,CDK,NF-kappaB,PERK,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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