ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2[1]. ML351 prevents dysglycemia and reduces beta-cell oxidative stress in nonobese diabetic mouse model of T1D[2].
Molecular Weight:
249.27
Purity:
99.16
CAS Number:
[847163-28-4]
Formula:
C15H11N3O
Target:
Lipoxygenase
Application Notes:
MCE Product type: Reference compound
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