SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 77 nM for hSPPL2a. SPL-707 inhibits gamma-secretase (IC50=6.1 µM) and SPP (IC50=3.7 µM). SPL-707 has the potential for autoimmune diseases research by targeting B cells and dendritic cells[1].
Molecular Weight:
505.54
Purity:
99.64
CAS Number:
[2195361-33-0]
Formula:
C27H28FN5O4
Target:
gamma-secretase
Application Notes:
MCE Product type: Reference compound1
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