UNC9994 hydrochloride is a functionally selective, beta-arrestin-biased dopamine D2 receptor (D2R) agonist that selectively activates beta-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a Ki of 79 nM for D2R. UNC9994 hydrochloride is also an antagonist of Gi-regulated cAMP production and partial agonist for D2R/beta-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity[1].
Molecular Weight:
457.84
Purity:
99.50
CAS Number:
[2108826-33-9]
Formula:
C21H23Cl3N2OS
Target:
5-HT Receptor,Arrestin,Dopamine Receptor
Application Notes:
Reference compound
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