RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC50 value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression[1].
Molecular Weight:
374.42
Purity:
99.65
CAS Number:
[955900-27-3]
Formula:
C16H18N6O3S
Target:
c-Myc,Sirtuin
Application Notes:
MCE Product type: Reference compound1
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