Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 µM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity[1].
Molecular Weight:
273.16
Purity:
99.91
CAS Number:
[369631-68-5]
Formula:
C11H6F3NO4
Target:
Arf Family GTPase
Application Notes:
MCE Product type: Reference compound1
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