PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity[1].
Molecular Weight:
474.56
Purity:
99.83
CAS Number:
[1417630-95-5]
Formula:
C25H30N8O2
Target:
Pim
Application Notes:
MCE Product type: Reference compound1
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