VUBI1 (SOS1 activator 1) is a benzimidazole derivative and SOS1 activator with a Kd of 44 nM. VUBI1 can significantly activate RAS-GTP and regulate the phosphorylation of ERK. VUBI1 also can serve as a target ligand for synthesizing PROTACs, such as PROTAC SOS1 degrader-1 (HY-145737), to induce SOS1 degradation. VUBI1 can be used in the study of cancer[1][2][3][4].
Molecular Weight:
483.02
Purity:
98.21
CAS Number:
[2245237-53-8]
Formula:
C26H32ClFN6
Target:
Ligands for Target Protein for PROTAC,PERK,Ras,SOS1
Application Notes:
MCE Product type: Reference compound
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