NRX-252114 is a potent enhancer of the interaction between beta-catenin, and its cognate E3 ligase, SCFbeta-TrCP. NRX-252114 enhances the binding of pSer33/S37A beta-catenin peptide for beta-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant beta-catenin degradation[1].
Molecular Weight:
510.32
Purity:
99.43
CAS Number:
[2763260-39-3]
Formula:
C22H12Cl2F3N3O2S
Target:
Molecular Glues,beta-catenin
Application Notes:
MCE Product type: Reference compound
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