SR-4995 (CID 16016685) is a highly effective and selective ligand for alpha-beta-hydrolase domain-containing 5 (ABHD5), facilitating the activation of adipose triglyceride lipase (ATGL) by displacing ABHD5 from its inhibitory regulators, perilipin-1 (PLIN1) and PLIN5. It directly interacts with ABHD5, inhibiting its association with PLIN1, and promotes lipolysis in adipocytes and muscle tissues while circumventing PKA-dependent signaling pathways.
Molecular Weight:
355.45
Purity:
98.26
CAS Number:
[891509-95-8]
Formula:
C19H21N3O2S
Target:
Endogenous Metabolite
Application Notes:
Reference compound
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