BAY-3827, a chemical probe, is a potent and selective AMPK inhibitor with IC50 values of 1.4 nM at low (10 µM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines[1].
Molecular Weight:
468.53
Purity:
99.72
CAS Number:
[2377576-35-5]
Formula:
C27H25FN6O
Target:
AMPK
Application Notes:
MCE Product type: Reference compound1
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