C188-9 (TTI-101) is a STAT3 inhibitor, with a Kd of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts[1][2][3][4].
Molecular Weight:
471.52
Purity:
99.84
CAS Number:
[432001-19-9]
Formula:
C27H21NO5S
Target:
Apoptosis,STAT
Application Notes:
MCE Product type: Reference compound
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