GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 µM. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis[1][2].
Molecular Weight:
573.55
Purity:
99.91
CAS Number:
[579515-63-2]
Formula:
C25H22F3N7O4S
Target:
Mixed Lineage Kinase,VEGFR
Application Notes:
MCE Product type: Reference compound
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