GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 µM. GW806742X hydrochloride has activity against VEGFR2 (IC50=2 nM). GW806742X hydrochloride retards MLKL membrane translocation and inhibits necroptosis[1][2].
Molecular Weight:
610.01
Purity:
98.30
Formula:
C25H23ClF3N7O4S
Target:
Mixed Lineage Kinase,VEGFR
Application Notes:
MCE Product type: Reference compound
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