PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-beta and EGFR (IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits MAPK with an IC50 of 7.1 µM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity[1].
Molecular Weight:
405.28
Purity:
98.07
CAS Number:
[179343-17-0]
Formula:
C18H18Cl2N6O
Target:
EGFR,FGFR,PDGFR,Src
Application Notes:
MCE Product type: Reference compound
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