Aloisine A (RP107) is a a potent cyclin-dependent kinase (CDK) inhibitor with IC50s of 0.15 µM, 0.12 µM, 0.4 µM, 0.16 µM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p35, respectively. Aloisine A ininhibits GSK-3alpha (IC50=0.5 µM) and GSK-3beta (IC50=1.5 µM). Aloisine A stimulates wild-type CFTR and mutated CFTR, with submicromolar affinity by a cAMP-independent mechanism. Aloisine A has the potential for CFTR-related diseases, including cystic fibrosis research[1][2].
Molecular Weight:
267.33
CAS Number:
[496864-16-5]
Formula:
C16H17N3O
Target:
CDK,CFTR,ERK,GSK-3,JNK
Application Notes:
MCE Product type: Reference compound
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