Aurora kinase inhibitor-3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50 of >10 µM. Aurora kinase inhibitor-3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket[1].
Molecular Weight:
413.40
Purity:
99.05
CAS Number:
[879127-16-9]
Formula:
C21H18F3N5O
Target:
Aurora Kinase
Application Notes:
MCE Product type: Reference compound
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