Ki11502 is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the activity of PDGF beta/alpha receptors with IC50 values less than 10 nM. Ki11502 selectively inhibits PDGF beta receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Ki11502 can induce Apoptosis) and exhibits profound antiproliferative effects on select subsets of leukemia, including those with Imatinib (HY-15463) resistant mutations. Ki11502 is highly suitable for studying the role of PDGF in vascular diseases, particularly the role of proteoglycans in atherosclerosis[1][2].
Molecular Weight:
473.54
Purity:
99.30
CAS Number:
[347155-76-4]
Formula:
C26H23N3O4S
Target:
Akt,Apoptosis,Bcl-2 Family,FLT3,PDGFR,PERK
Application Notes:
MCE Product type: Reference compound
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