CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis[1].
Molecular Weight:
454.56
Purity:
98.70
CAS Number:
[1034297-58-9]
Formula:
C28H30N4O2
Target:
PKD
Application Notes:
MCE Product type: Reference compound
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