Ivarmacitinib (SHR0302) is a potent and orally active all members of the JAK family inhibitor, particularly JAK1. The selectivity of Ivarmacitinib for JAK1 is >10-fold for JAK2, 77-fold for JAK3, 420-fold for Tyk2. Ivarmacitinib inhibits JAK1-STAT3 phosphorylation and induces the apoptosis of hepatic stellate cells. Ivarmacitinib has anti-proliferative and anti-inflammatory effects[1][2].
Molecular Weight:
414.48
Purity:
99.62
CAS Number:
[1445987-21-2]
Formula:
C18H22N8O2S
Target:
Apoptosis,JAK
Application Notes:
MCE Product type: Reference compound
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