TSI-01 is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s=0.47 versus 3.02 µM for human LPCAT2 and LPCAT1, respectively). 60 µM it is shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.
Molecular Weight:
328.15
Purity:
98.52
CAS Number:
[704878-75-1]
Formula:
C14H11Cl2NO4
Target:
Platelet-activating Factor Receptor (PAFR)
Application Notes:
Reference compound
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