BMS-681 is an orthosteric antagonist of CC chemokine receptor 2 (CCR2). BMS-681 restricts the movement of the extracellular end of TM6 by stabilizing TM7. TM7 and TM6 are the main components of the orthosteric binding site. BMS-681 can be used to study inflammatory neurodegenerative diseases and cancer[1].
Molecular Weight:
491.59
CAS Number:
[847998-92-9]
Formula:
C26H36F3N5O
Target:
CCR
Application Notes:
MCE Product type: Reference compound
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