N2,N2-Dimethylguanosine is a methylated nucleoside present in RNA and a structural modification component of tRNA. N2,N2-Dimethylguanosine hinders reverse transcriptase-mediated cDNA synthesis and is one of the key modifications that affect sequencing efficiency in high-throughput RNA sequencing. N2,N2-Dimethylguanosine can selectively remove one of the methyl groups through AlkB mutant enzymes (such as D135S/L118V) and convert it into N2-methylguanosine, thereby reducing the hindrance to reverse transcription[1][2].
Molecular Weight:
311.29
Purity:
99.40
CAS Number:
[2140-67-2]
Formula:
C12H17N5O5
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Natural Products
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