Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2, HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimers (AD) and Parkinsons diseases (PD)[1][2][3][4].
Molecular Weight:
334.45
Purity:
98.10
CAS Number:
[60203-57-8]
Formula:
C20H30O4
Target:
Endogenous Metabolite,Prostaglandin Receptor
Application Notes:
MCE Product type: Reference compound1
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