12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-kappaB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].
Molecular Weight:
320.47
Purity:
95.70
CAS Number:
[71030-37-0]
Formula:
C20H32O3
Target:
Apoptosis
Application Notes:
MCE Product type: Reference compound
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