9(R)-HODE (9(R)-Hydroxyoctadecadienoic acid) is a monohydroxy fatty acid and metabolite of linoleic acid. It is formed from linoleic acid by COX and lipoxygenase (LO).9(R)-HODE induces chemotaxis, increases the levels of chemokine (C-C motif) receptor 9 (CCR9) and chemokine (C-X-C motif) receptor 4 (CXCR4), and inhibits IL-6 release in primary human monocytes. It inhibits CD3alpha- and CD28-induced proliferation of isolated human peripheral blood lymphocytes when used at a concentration of 25 µg/mL.
Molecular Weight:
296.44
CAS Number:
[10075-11-3]
Formula:
C18H32O3
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Natural Products
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