Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-kappaB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular [1][2][3][4][5].
Molecular Weight:
284.26
Purity:
99.87
CAS Number:
[102067-84-5]
Formula:
C16H12O5
Target:
Akt,COX,ERK,Interleukin Related,JNK,Keap1-Nrf2,NF-kappaB,NO Synthase,Nuclear Factor of activated T Cells (NFAT),p38 MAPK,Phosphodiesterase (PDE),Reactive Oxygen Species (ROS),TNF Receptor
Application Notes:
MCE Product type: Natural Products
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