ts-SA is a carbonic anhydrase (CA) inhibitor with activity against seven human CA homologues. ts-SA can bind to the Zn(II) ion in the enzyme active site in a deprotonated form. The organic skeleton of ts-SA extends in the enzyme cavity and participates in multiple interactions with amino acid residues and water molecules. Due to its structural differences, the inhibitory performance of ts-SA is significantly better than that of another pyridine derivative. ts-SA exhibits low nanomolar inhibitory activity and is a multi-target CA inhibitor[1].
Molecular Weight:
369.42
CAS Number:
[100715-13-7]
Formula:
C14H15N3O5S2
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound
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