S-8666 is an orally active uricosuric antihypertensive diuretic. The S-8666 has both S-(-)- and R-(+)-isomers. The diuretic and sodium-excretion activities of it are entirely dominated by the S-(-)-isomer, while the R-(+)-isomer shows no significant activity. S-8666 relies on the organic acid transport system to be secreted through the proximal tubule. S-8666 exhibits a clear uric acid excretion-promoting activity and diuretic effect in various species (such as rats and chimpanzees)[1][2].
Molecular Weight:
340.18
CAS Number:
[103968-87-2]
Formula:
C11H11Cl2NO5S
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound
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