L 668411 is a beta-lactone inhibitor with activity against 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis. L 668411 inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and [14C] acetate incorporation into sterols in cultured Hep G2 cells, and the inhibition appears to be irreversible in cells but reversible in cultured cells and animals.
Molecular Weight:
338.44
CAS Number:
[112965-15-8]
Formula:
C19H30O5
Target:
HMG-CoA Reductase (HMGCR)
Application Notes:
MCE Product type: Reference compound
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