THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor alpha and PPARgamma with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma[1][2].
Molecular Weight:
266.33
Purity:
98.00
CAS Number:
[100079-26-3]
Formula:
C15H22O4
Target:
Nuclear Hormone Receptor 4A/NR4A
Application Notes:
MCE Product type: Reference compound
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